A SIGNALING VIEW INTO THE INFLAMMATORY TUMOR MICROENVIRONMENT

A Signaling View into the Inflammatory Tumor Microenvironment

The development of tumors requires an initiator event, usually exposure to DNA damaging agents that cause genetic alterations such as gene mutations or chromosomal abnormalities, leading to deregulated cell proliferation.Although the mere stochastic accumulation of further mutations may cause tumor progression, it is now clear that an inflammatory

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Investigating the Marshall and Volumetric Properties of Asphalt Concrete Containing Reclaimed Asphalt Pavement and Waste Oils Using Response Surface Methodology

This research aimed to use response surface methodology (RSM) for investigating the Marshall Stability (MS), flow and Voids in Mineral Aggregates (VMA) of asphalt concrete containing different percentages of Reclaimed Asphalt Pavement (RAP) and rejuvenated by different percentages of waste cooking and engine oil.Variables of RAP content in 3 differ

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RecurIndex assay as an aid for adjuvant chemotherapy decisions in HR-positive HER2-negative breast cancer patients

BackgroundAdjuvant chemotherapy is a major adjuvant treatment modality for hormonal receptor (HR)-positive and HER2-negative early breast cancer, but only 2%-20% of patients derive practical benefits.How to balance its potential benefits and Eyebright risks becomes a challenging clinical problem.The purpose of this study was to assess whether Recur

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The Medieval Problem of the Productivity of Art

This Duvet Set paper is focused on one of the key questions constituting the medieval debate about the ontological status of artefacts, which has to do with the productivity of art.We ordinarily speak about artefacts, such as statues or chairs, as produced by their artificers, and Aristotle describes art in general as a productive habit.In the firs

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